BAIT

UBC

HMG20
ubiquitin C
GO Process (75)
GO Function (3)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

OR7G3

OST085
olfactory receptor, family 7, subfamily G, member 3
GO Process (2)
GO Function (1)
GO Component (2)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

Nathan JA, Tae Kim H, Ting L, Gygi SP, Goldberg AL

Although cellular proteins conjugated to K48-linked Ub chains are targeted to proteasomes, proteins conjugated to K63-ubiquitin chains are directed to lysosomes. However, pure 26S proteasomes bind and degrade K48- and K63-ubiquitinated substrates similarly. Therefore, we investigated why K63-ubiquitinated proteins are not degraded by proteasomes. We show that mammalian cells contain soluble factors that selectively bind to K63 chains and inhibit ... [more]

EMBO J. Jan. 11, 2013; 0(0); [Pubmed: 23314748]

Throughput

  • High Throughput

Additional Notes

  • #LPPI
  • Likely protein-protein interaction
  • binds K63-linked poly-ubiquitin chains in vitro
  • identified by MS

Curated By

  • BioGRID