DAPK1
Gene Ontology Biological Process
- apoptotic process [IGI, IMP, TAS]
- apoptotic signaling pathway [IMP]
- cellular response to interferon-gamma [IDA]
- intracellular signal transduction [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- protein autophosphorylation [IDA, TAS]
- protein phosphorylation [IDA, TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of apoptotic process [IBA, TAS]
- regulation of autophagy [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYL12B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.
Death-associated protein kinase (DAPK) is a death domain-containing serine/threonine kinase, and participates in various apoptotic paradigms. Here, we identify the extracellular signal-regulated kinase (ERK) as a DAPK-interacting protein. DAPK interacts with ERK through a docking sequence within its death domain and is a substrate of ERK. Phosphorylation of DAPK at Ser 735 by ERK increases the catalytic activity of DAPK ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID