BAIT
USP2
UBP41, USP9
ubiquitin specific peptidase 2
GO Process (10)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- circadian behavior [ISS]
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- locomotor rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of mitotic cell cycle [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- protein stabilization [IDA, IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Homo sapiens
PREY
MNAT1
CAP35, MAT1, RNF66, TFB3
MNAT CDK-activating kinase assembly factor 1
GO Process (25)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- ATP catabolic process [IDA]
- DNA repair [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- cell proliferation [TAS]
- gene expression [TAS]
- mitotic cell cycle [TAS]
- nucleotide-excision repair [TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of viral transcription [TAS]
- protein complex assembly [TAS]
- protein phosphorylation [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.
The opposing regulators of ubiquitylation status, E3 ligases and deubiquitylases, are often found to be associated in complexes. Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. We map the interaction to the N-terminal DUSP-UBL ... [more]
J. Biol. Chem. Dec. 14, 2012; 287(51);43007-18 [Pubmed: 23105109]
Throughput
- High Throughput
Curated By
- BioGRID