BAIT
USP5
ISOT
ubiquitin specific peptidase 5 (isopeptidase T)
GO Process (2)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRIM5
RNF88, TRIM5alpha
tripartite motif containing 5
GO Process (13)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- activation of innate immune response [IDA]
- defense response to virus [TAS]
- innate immune response [IDA]
- negative regulation of viral entry into host cell [IDA]
- negative regulation of viral release from host cell [IDA]
- pattern recognition receptor signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- protein K63-linked ubiquitination [IDA]
- protein trimerization [IDA]
- regulation of lipopolysaccharide-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.
The opposing regulators of ubiquitylation status, E3 ligases and deubiquitylases, are often found to be associated in complexes. Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. We map the interaction to the N-terminal DUSP-UBL ... [more]
J. Biol. Chem. Dec. 14, 2012; 287(51);43007-18 [Pubmed: 23105109]
Throughput
- High Throughput
Curated By
- BioGRID