BAIT
TNFAIP3
A20, OTUD7C, TNFA1P2, RP11-356I2.3
tumor necrosis factor, alpha-induced protein 3
GO Process (37)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- B-1 B cell homeostasis [ISS]
- cellular response to hydrogen peroxide [ISS]
- cellular response to lipopolysaccharide [IDA]
- innate immune response [TAS]
- negative regulation of B cell activation [ISS]
- negative regulation of CD40 signaling pathway [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of bone resorption [NAS]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of inflammatory response [ISS]
- negative regulation of innate immune response [ISS]
- negative regulation of interleukin-2 production [IMP]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of osteoclast proliferation [NAS]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of toll-like receptor 2 signaling pathway [NAS]
- negative regulation of toll-like receptor 3 signaling pathway [IDA]
- negative regulation of toll-like receptor 4 signaling pathway [NAS]
- negative regulation of tumor necrosis factor production [ISS]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of protein catabolic process [IDA]
- protein K11-linked deubiquitination [IDA]
- protein K48-linked deubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- protein deubiquitination [TAS]
- protein oligomerization [NAS]
- regulation of defense response to virus by host [NAS]
- regulation of germinal center formation [ISS]
- regulation of vascular wound healing [NAS]
- response to molecule of bacterial origin [IDA]
- tolerance induction to lipopolysaccharide [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RNF14
ARA54, HFB30, TRIAD2, HRIHFB2038
ring finger protein 14
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein ubiquitination [IEP]
- regulation of androgen receptor signaling pathway [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.
The opposing regulators of ubiquitylation status, E3 ligases and deubiquitylases, are often found to be associated in complexes. Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. We map the interaction to the N-terminal DUSP-UBL ... [more]
J. Biol. Chem. Dec. 14, 2012; 287(51);43007-18 [Pubmed: 23105109]
Throughput
- High Throughput
Curated By
- BioGRID