BAIT
TNFAIP3
A20, OTUD7C, TNFA1P2, RP11-356I2.3
tumor necrosis factor, alpha-induced protein 3
GO Process (37)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- B-1 B cell homeostasis [ISS]
- cellular response to hydrogen peroxide [ISS]
- cellular response to lipopolysaccharide [IDA]
- innate immune response [TAS]
- negative regulation of B cell activation [ISS]
- negative regulation of CD40 signaling pathway [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of bone resorption [NAS]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of inflammatory response [ISS]
- negative regulation of innate immune response [ISS]
- negative regulation of interleukin-2 production [IMP]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of osteoclast proliferation [NAS]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of toll-like receptor 2 signaling pathway [NAS]
- negative regulation of toll-like receptor 3 signaling pathway [IDA]
- negative regulation of toll-like receptor 4 signaling pathway [NAS]
- negative regulation of tumor necrosis factor production [ISS]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of protein catabolic process [IDA]
- protein K11-linked deubiquitination [IDA]
- protein K48-linked deubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- protein deubiquitination [TAS]
- protein oligomerization [NAS]
- regulation of defense response to virus by host [NAS]
- regulation of germinal center formation [ISS]
- regulation of vascular wound healing [NAS]
- response to molecule of bacterial origin [IDA]
- tolerance induction to lipopolysaccharide [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRIM3
BERP, HAC1, RNF22, RNF97
tripartite motif containing 3
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.
The opposing regulators of ubiquitylation status, E3 ligases and deubiquitylases, are often found to be associated in complexes. Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. We map the interaction to the N-terminal DUSP-UBL ... [more]
J. Biol. Chem. Dec. 14, 2012; 287(51);43007-18 [Pubmed: 23105109]
Throughput
- High Throughput
Curated By
- BioGRID