BAIT
PRKCB
Pkcb, Prkcb1
protein kinase C, beta
GO Process (25)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- B cell activation [ISO, ISS]
- B cell receptor signaling pathway [ISO, ISS]
- calcium ion transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to carbohydrate stimulus [ISO]
- dibenzo-p-dioxin metabolic process [IEP]
- histone H3-T6 phosphorylation [ISO, ISS]
- intracellular signal transduction [NAS]
- negative regulation of glucose transport [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [IDA]
- positive regulation of B cell receptor signaling pathway [ISO, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of angiogenesis [ISO, ISS]
- positive regulation of odontogenesis of dentin-containing tooth [IEP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of dopamine secretion [IMP]
- regulation of growth [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- response to drug [IMP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hypoxia [ISO]
- response to vitamin D [IEP]
Gene Ontology Molecular Function- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GJA1
Cx43
gap junction protein, alpha 1
GO Process (61)
GO Function (10)
GO Component (28)
Gene Ontology Biological Process
- ATP transport [IMP]
- adult heart development [ISO]
- apoptotic process [IMP]
- atrial ventricular junction remodeling [ISO]
- blood vessel morphogenesis [ISO]
- cardiac conduction [ISO]
- cell communication [IMP]
- cell communication by chemical coupling [ISO]
- cell communication by electrical coupling [ISO]
- cell-cell junction organization [ISO]
- cell-cell signaling [IDA, ISO]
- cellular response to mechanical stimulus [IEP]
- chronic inflammatory response [IMP]
- embryonic digit morphogenesis [ISO]
- embryonic heart tube development [ISO]
- endothelium development [IEP]
- epithelial cell maturation [ISO]
- gap junction assembly [TAS]
- heart development [IEP, ISO]
- heart looping [ISO]
- in utero embryonic development [ISO]
- lens development in camera-type eye [ISO]
- milk ejection [ISO]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of wound healing [IMP]
- neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- osteoblast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [IMP]
- positive regulation of cell communication by chemical coupling [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of glomerular filtration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of protein catabolic process [IDA]
- positive regulation of striated muscle tissue development [ISO]
- positive regulation of vasoconstriction [IMP]
- positive regulation of vasodilation [IMP]
- protein oligomerization [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of bone mineralization [ISO]
- regulation of bone remodeling [ISO]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [ISO]
- regulation of tight junction assembly [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to fluid shear stress [IEP]
- response to glucose [IEP]
- response to pH [IDA]
- response to peptide hormone [IEP]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [ISO]
- transmembrane transport [IDA, ISO]
- vascular transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- apical plasma membrane [ISO]
- cell junction [ISO]
- cell-cell junction [ISO]
- connexon complex [IDA]
- contractile fiber [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [IDA]
- endoplasmic reticulum membrane [TAS]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- integral component of plasma membrane [TAS]
- intercalated disc [ISO]
- intermediate filament [ISO]
- late endosome [IDA]
- lateral plasma membrane [ISO]
- lysosome [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [IDA]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP, ISO, TAS]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.
Phorbol esters (e.g., TPA) activate protein kinase C (PKC), increase connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types. We asked whether PKC directly phosphorylates and regulates Cx43. Rat epithelial T51B cells metabolically labeled with (32)P(i) yielded two-dimensional phosphotryptic maps of Cx43 with several phosphopeptides that increased in intensity upon TPA treatment. One of these ... [more]
J. Cell Biol. Jun. 26, 2000; 149(7);1503-12 [Pubmed: 10871288]
Throughput
- Low Throughput
Curated By
- BioGRID