ADCY8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP2CA
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- mesoderm development [IMP]
- negative regulation of calcium ion transmembrane transporter activity [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription factor import into nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphatase type 2A activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [ISO, TAS]
- protein heterotrimerization [ISO]
- regulation of cell cycle [TAS]
- regulation of protein autophosphorylation [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.
Although protein scaffolding complexes compartmentalize protein kinase A (PKA) and phosphodiesterases to optimize cAMP signaling, adenylyl cyclases, the sources of cAMP, have been implicated in very few direct protein interactions. The N termini of adenylyl cyclases are highly divergent, which hints at isoform-specific interactions. Indeed, the Ca(2+)-sensitive adenylyl cyclase 8 (AC8) contains a Ca(2+)/calmodulin binding site on the N terminus ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID