SET
Gene Ontology Biological Process
- DNA replication [TAS]
- RNA metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of catalytic activity [TAS]
- negative regulation of histone acetylation [TAS]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- nucleocytoplasmic transport [NAS]
- nucleosome disassembly [TAS]
- regulation of catalytic activity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IRF1
Gene Ontology Biological Process
- apoptotic process [IDA]
- blood coagulation [TAS]
- cell cycle arrest [IDA]
- cellular response to interferon-beta [IDA]
- cellular response to mechanical stimulus [IEP]
- cytokine-mediated signaling pathway [TAS]
- defense response to virus [IDA]
- interferon-gamma-mediated signaling pathway [ISS, TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of regulatory T cell differentiation [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of interferon-beta production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [ISS]
- regulation of CD8-positive, alpha-beta T cell proliferation [ISS]
- regulation of MyD88-dependent toll-like receptor signaling pathway [ISS]
- regulation of adaptive immune response [TAS]
- regulation of cell cycle [TAS]
- regulation of innate immune response [TAS]
- transcription from RNA polymerase II promoter [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
DNA-binding regulates site-specific ubiquitination of IRF-1.
Understanding the determinants for site-specific ubiquitination by E3 ligase components of the ubiquitin machinery is proving to be a challenge. In the present study we investigate the role of an E3 ligase docking site (Mf2 domain) in an intrinsically disordered domain of IRF-1 [IFN (interferon) regulatory factor-1], a short-lived IFNγ-regulated transcription factor, in ubiquitination of the protein. Ubiquitin modification of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID