NEDD4L
Gene Ontology Biological Process
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein localization to cell surface [ISO]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- negative regulation of sodium ion transport [IDA, IMP, ISO]
- negative regulation of systemic arterial blood pressure [IMP]
- positive regulation of cation channel activity [IGI]
- positive regulation of caveolin-mediated endocytosis [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of sodium ion transport [IGI]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K48-linked ubiquitination [ISO]
- protein monoubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane depolarization [ISO]
- regulation of membrane potential [ISO]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- regulation of tight junction assembly [IDA]
- response to metal ion [ISO]
- response to salt stress [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IDA, IGI]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- ion channel binding [ISO]
- potassium channel inhibitor activity [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- sodium channel inhibitor activity [IDA, ISO]
- sodium channel regulator activity [ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IBA, ISO]
- ion channel binding [ISO]
- potassium channel inhibitor activity [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- sodium channel inhibitor activity [IDA, ISO]
- sodium channel regulator activity [ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IBA, ISO]
Gene Ontology Cellular Component
SLC12A1
Gene Ontology Biological Process
- cation transmembrane transport [IDA]
- chemical homeostasis [IMP]
- chloride transmembrane transport [IDA, ISO]
- chloride transport [ISO]
- excretion [IMP]
- ion transmembrane transport [ISO]
- kidney development [IMP]
- potassium ion transport [ISO]
- protein insertion into membrane from inner side [ISO]
- renal rubidium ion absorption [ISO]
- sodium ion transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Synergistical effect of 20-HETE and high salt on NKCC2 protein and blood pressure via ubiquitin-proteasome pathway.
We previously generated a cytochrome P450 4F2 (CYP4F2) transgenic mouse model and demonstrated that overexpressed CYP4F2 and overproduced 20-HETE in the kidneys contribute to the increase of blood pressure in the CYP4F2 transgenic mice with normal salt intake. We currently expect to elucidate a potential mechanism of salt-related hypertension whereby diverse levels of 20-HETE interact with dietary salt on Na(+)-K(+)-2Cl(-) ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC12A1 NEDD4L | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID