Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.

Ambivero CT, Cilenti L, Zervos AS

Abro1 (Abraxas brother 1), also known as KIAA0157, is a scaffold protein that recruits various polypeptides to assemble the BRISC (BRCC36 isopeptide) deubiquitinating enzyme (DUB) complex. The BRISC enzyme has a Lys63-linked deubiquitinating activity and is comprised of four known subunits: MERIT40 (mediator of Rap80 interactions and targeting 40kDa), BRE (brain and reproductive organ-expressed), BRCC36 (BRCA1/BRCA2-containing complex, subunit 3) and ... [more]

Biochim. Biophys. Acta Dec. 01, 2012; 1823(12);2149-56 [Pubmed: 22974638]

Throughput

Low Throughput

Additional Notes

#LPPI
Likely protein-protein interaction

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
UBC FAM175B	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	McLelland GL (2018)	Low	-	BioGRID	2513478

Curated By

BioGRID

Interaction Summary

FAM175B

Gene Ontology Biological Process

Gene Ontology Molecular Function

polyubiquitin binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component

UBC

Gene Ontology Biological Process

Gene Ontology Molecular Function

poly(A) RNA binding [ISO]protease binding [ISO]protein binding [IPI]