BAIT
CLN8
C8orf61, EPMR
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
GO Process (9)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
BNIP3
NIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
GO Process (24)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- apoptotic process [IPI]
- cell death [ISS]
- cellular response to cobalt ion [IMP]
- cellular response to hypoxia [IMP]
- cellular response to mechanical stimulus [IEP]
- defense response to virus [IDA]
- granzyme-mediated apoptotic signaling pathway [IDA]
- intrinsic apoptotic signaling pathway in response to hypoxia [IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA]
- mitochondrial outer membrane permeabilization [IDA]
- mitochondrial protein catabolic process [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of membrane potential [IDA]
- negative regulation of mitochondrial fusion [IDA]
- neuron apoptotic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of autophagy [TAS]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of programmed cell death [IDA]
- positive regulation of protein complex disassembly [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- response to hypoxia [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.
Neuronal ceroid lipofuscinoses (NCLs) are a genetically heterogeneous group of neurodegenerative diseases characterized by cognitive and motor decline, epilepsy, visual loss and by lysosomal autofluorescent inclusions. Two distinct clinical phenotypes, the progressive epilepsy with mental retardation (EPMR) and a late-infantile variant of NCLs (CLN8-vLINCL) are associated with mutations in the CLN8 gene that encodes a transmembrane protein predominantly located to ... [more]
Biochim. Biophys. Acta Mar. 01, 2013; 1833(3);529-40 [Pubmed: 23142642]
Throughput
- Low Throughput
Curated By
- BioGRID