BAIT
CLN8
C8orf61, EPMR
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
GO Process (9)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
NDRG2
SYLD
NDRG family member 2
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.
Neuronal ceroid lipofuscinoses (NCLs) are a genetically heterogeneous group of neurodegenerative diseases characterized by cognitive and motor decline, epilepsy, visual loss and by lysosomal autofluorescent inclusions. Two distinct clinical phenotypes, the progressive epilepsy with mental retardation (EPMR) and a late-infantile variant of NCLs (CLN8-vLINCL) are associated with mutations in the CLN8 gene that encodes a transmembrane protein predominantly located to ... [more]
Biochim. Biophys. Acta Mar. 01, 2013; 1833(3);529-40 [Pubmed: 23142642]
Throughput
- Low Throughput
Curated By
- BioGRID