BAIT

CLN8

C8orf61, EPMR
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Homo sapiens
PREY

CYB5B

CYB5-M, CYPB5M, OMB5, RP11-140H17.1
cytochrome b5 type B (outer mitochondrial membrane)
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.

Passantino R, Cascio C, Deidda I, Galizzi G, Russo D, Spedale G, Guarneri P

Neuronal ceroid lipofuscinoses (NCLs) are a genetically heterogeneous group of neurodegenerative diseases characterized by cognitive and motor decline, epilepsy, visual loss and by lysosomal autofluorescent inclusions. Two distinct clinical phenotypes, the progressive epilepsy with mental retardation (EPMR) and a late-infantile variant of NCLs (CLN8-vLINCL) are associated with mutations in the CLN8 gene that encodes a transmembrane protein predominantly located to ... [more]

Biochim. Biophys. Acta Mar. 01, 2013; 1833(3);529-40 [Pubmed: 23142642]

Throughput

  • Low Throughput

Curated By

  • BioGRID