BAIT
EDNRA
ET-AR, ETa, Gpcr10
endothelin receptor type A
GO Process (38)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- Rho protein signal transduction [ISO]
- artery smooth muscle contraction [ISO]
- cellular response to mechanical stimulus [ISO]
- endothelin receptor signaling pathway [IMP, ISO]
- fibroblast proliferation [ISO]
- glomerular filtration [ISO]
- glucose transport [IDA]
- head development [IMP]
- heart development [IGI]
- histamine secretion [ISO]
- in utero embryonic development [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cAMP biosynthetic process [IGI]
- neural crest cell development [IMP]
- patterning of blood vessels [IGI]
- penile erection [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of kidney development [ISO]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of odontogenesis [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO]
- regulation of blood pressure [IMP]
- regulation of epithelial cell proliferation [ISO]
- respiratory gaseous exchange [IMP]
- response to hypoxia [IMP]
- response to lipopolysaccharide [ISO]
- response to morphine [ISO]
- sensory perception of pain [ISO]
- smooth muscle cell proliferation [ISO]
- vasoconstriction [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARRB1
1200006I17Rik, AW208571, G430100A01Rik
arrestin, beta 1
GO Process (34)
GO Function (19)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [ISO]
- endocytosis [ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein binding [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of smooth muscle cell apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [ISO]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- estrogen receptor binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [ISO]
- mitogen-activated protein kinase kinase binding [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein phosphorylated amino acid binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [ISO]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- estrogen receptor binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [ISO]
- mitogen-activated protein kinase kinase binding [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein phosphorylated amino acid binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
The insulin and the endothelin type A (ETA) receptor both can couple into the heterotrimeric G protein alpha(q/11) (Galpha(q/11)), leading to Galpha(q/11) tyrosine phosphorylation, phosphatidylinositol 3-kinase activation, and subsequent stimulation of glucose transport. In this study, we assessed the potential role of Src kinase in ET-1 signaling to glucose transport in 3T3-L1 adipocytes. Src kinase inhibitor PP2 blocked ET-1-induced Src ... [more]
J. Biol. Chem. Nov. 23, 2001; 276(47);43663-7 [Pubmed: 11546805]
Throughput
- Low Throughput
Curated By
- BioGRID