KIN1
Gene Ontology Biological Process
Gene Ontology Cellular Component
PPB1
Gene Ontology Biological Process
- calcium-mediated signaling [IMP]
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- cytosolic calcium ion homeostasis [IMP]
- fungal-type cell wall organization or biogenesis [IGI]
- negative regulation of calcium ion transport into cytosol [IMP]
- protein dephosphorylation [IC]
- regulation of conjugation with cellular fusion [IMP]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- regulation of mitotic cytokinesis [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.
BACKGROUND INFORMATION: The Kin1 protein kinase of fission yeast, which regulates cell surface cohesiveness during interphase cell growth, is also present at the cell division site during mitosis; however, its function in cell division has remained elusive. RESULTS: In FK506-mediated calcineurin deficient cells, mitosis is extended and ring formation is transiently compromised but septation remains normal. Here we show that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KIN1 PPB1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 816307 | |
| KIN1 PPB1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 816317 |
Curated By
- BioGRID