BAIT

KIN1

SPBC4F6.06
microtubule affinity-regulating kinase Kin1
Schizosaccharomyces pombe (972h)
PREY

PCK1

SPAC22H10.01c, SPAC17G8.14c
protein kinase C (PKC)-like Pck1
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.

Cadou A, Couturier A, Le Goff C, Xie L, Paulson JR, Le Goff X

BACKGROUND INFORMATION: The Kin1 protein kinase of fission yeast, which regulates cell surface cohesiveness during interphase cell growth, is also present at the cell division site during mitosis; however, its function in cell division has remained elusive. RESULTS: In FK506-mediated calcineurin deficient cells, mitosis is extended and ring formation is transiently compromised but septation remains normal. Here we show that ... [more]

Biol. Cell Jan. 08, 2013; 0(0); [Pubmed: 23294323]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: septum formation (APO:0000221)

Additional Notes

  • In the presence of FK506 and 1NM-PP1, kin1-as1/pck1 double mutants showed suppression of the aberrant septa seen in kin1-as1 cells

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
KIN1 PCK1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-8.5299BioGRID
774579
KIN1 PCK1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
448509
KIN1 PCK1
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
816718

Curated By

  • BioGRID