BAIT
CAV1
Cav, Cav-1
caveolin 1, caveolae protein
GO Process (89)
GO Function (15)
GO Component (28)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- T cell costimulation [ISO]
- angiogenesis [IGI]
- apoptotic signaling pathway [ISO]
- calcium ion homeostasis [IMP]
- calcium ion transport [IMP]
- caveola assembly [IMP, ISO]
- caveolin-mediated endocytosis [ISO]
- cellular calcium ion homeostasis [IMP, ISO]
- cellular response to hyperoxia [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IMP]
- cellular senescence [ISO]
- cholesterol efflux [ISO]
- cholesterol homeostasis [IMP]
- cytosolic calcium ion homeostasis [ISO]
- endocytosis [TAS]
- inactivation of MAPK activity [IMP]
- lactation [IMP]
- lipid storage [IMP]
- maintenance of protein location in cell [ISO]
- mammary gland development [IMP]
- mammary gland involution [IMP]
- membrane depolarization [IMP]
- microtubule polymerization [ISO]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of JAK-STAT cascade [IDA, IGI, IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of anoikis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cation channel activity [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytokine-mediated signaling pathway [IMP]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of nitric oxide biosynthetic process [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-tyrosine autophosphorylation [ISO]
- negative regulation of pinocytosis [ISO]
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of protein ubiquitination [IMP, ISO]
- negative regulation of signal transduction [IDA]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IDA, IMP]
- nitric oxide homeostasis [IMP]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of peptidase activity [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of signal transduction [ISO]
- positive regulation of vasoconstriction [IMP, ISO]
- protein homooligomerization [IDA]
- protein localization [IMP]
- protein oligomerization [IDA]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of blood coagulation [ISO]
- regulation of fatty acid metabolic process [IMP]
- regulation of inward rectifier potassium channel activity [ISO]
- regulation of membrane repolarization during action potential [ISO]
- regulation of peptidase activity [IMP]
- regulation of smooth muscle contraction [IMP]
- regulation of the force of heart contraction [IMP]
- regulation of the force of heart contraction by chemical signal [IGI]
- response to calcium ion [IDA]
- response to estrogen [IDA, ISO]
- response to hypoxia [IMP]
- response to ischemia [IMP]
- response to mechanical stimulus [ISO]
- response to progesterone [ISO]
- skeletal muscle tissue development [IMP]
- triglyceride metabolic process [IMP]
- vasculogenesis [IMP]
- vasoconstriction [IMP]
- vesicle organization [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [ISO]
- RNA polymerase I transcription factor binding [ISO]
- SNARE binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel inhibitor activity [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- nitric-oxide synthase binding [ISO]
- peptidase activator activity [IMP]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [ISO]
- structural molecule activity [ISO]
- syntaxin binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- RNA polymerase I transcription factor binding [ISO]
- SNARE binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel inhibitor activity [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- nitric-oxide synthase binding [ISO]
- peptidase activator activity [IMP]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [ISO]
- structural molecule activity [ISO]
- syntaxin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [ISO]
- acrosomal membrane [IDA]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- caveola [IDA, ISO, TAS]
- cell [IMP]
- cell cortex [IDA]
- cell surface [ISO]
- cilium [IDA]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO]
- endosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [IDA]
- integral component of plasma membrane [IDA]
- intracellular [IMP, ISO]
- lipid particle [ISO]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrion [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- peroxisomal membrane [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IPI, ISO]
Mus musculus
PREY
JAK2
Fd17
Janus kinase 2
GO Process (80)
GO Function (17)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- JAK-STAT cascade [IDA, IMP, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, IMP, ISO]
- STAT protein import into nucleus [IDA]
- activation of JAK2 kinase activity [IDA]
- activation of MAPKK activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IDA]
- axon regeneration [ISO]
- cell differentiation [IMP]
- cell migration [IBA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to lipopolysaccharide [IDA]
- cytokine-mediated signaling pathway [IMP, ISO, TAS]
- enzyme linked receptor protein signaling pathway [IDA]
- erythrocyte differentiation [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO]
- hormone-mediated signaling pathway [ISO]
- host programmed cell death induced by symbiont [IDA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- mammary gland epithelium development [IMP]
- mineralocorticoid receptor signaling pathway [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of neuron apoptotic process [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell activation [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of growth hormone receptor signaling pathway [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- protein autophosphorylation [IDA, ISO]
- regulation of cell adhesion [IBA]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to granulocyte macrophage colony-stimulating factor [NAS]
- response to hydroperoxide [ISO]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [IDA]
- response to oxidative stress [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [IDA, IMP]
- tyrosine phosphorylation of Stat1 protein [ISO]
- tyrosine phosphorylation of Stat3 protein [ISO]
- tyrosine phosphorylation of Stat5 protein [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
It is well established that mammary gland development and lactation are tightly controlled by prolactin signaling. Binding of prolactin to its cognate receptor (Prl-R) leads to activation of the Jak-2 tyrosine kinase and the recruitment/tyrosine phosphorylation of STAT5a. However, the mechanisms for attenuating the Prl-R/Jak-2/STAT5a signaling cascade are just now being elucidated. Here, we present evidence that caveolin-1 functions as ... [more]
Mol. Biol. Cell Oct. 01, 2002; 13(10);3416-30 [Pubmed: 12388746]
Throughput
- Low Throughput
Ontology Terms
- tissue: mammary gland (BTO:0000817)
- tissue: mammary gland (UBERON:0001911)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JAK2 CAV1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 816401 |
Curated By
- BioGRID