NEUROD1
Gene Ontology Biological Process
- amacrine cell differentiation [IDA]
- anterior/posterior pattern specification [IMP]
- camera-type eye development [IGI]
- cell fate commitment [IGI]
- cellular response to glucose stimulus [ISO]
- cerebellum development [IMP]
- dentate gyrus development [IGI, IMP]
- embryonic organ morphogenesis [IMP]
- endocrine pancreas development [IMP]
- enteroendocrine cell differentiation [IMP]
- glucose homeostasis [IMP]
- hindbrain development [IMP]
- inner ear development [IMP]
- insulin secretion [ISO]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of type B pancreatic cell apoptotic process [IMP]
- nitric oxide mediated signal transduction [ISO]
- nucleocytoplasmic transport [ISO]
- pancreatic A cell fate commitment [IGI]
- pancreatic PP cell fate commitment [IGI]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell differentiation [IDA]
- positive regulation of neuron differentiation [IDA, ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell cycle arrest [IMP]
- regulation of intestinal epithelial structure maintenance [IDA]
- regulation of neuron differentiation [IGI]
- response to glucose [ISO]
- signal transduction involved in regulation of gene expression [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- DNA binding [IDA]
- E-box binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
NR4A1
Gene Ontology Biological Process
- apoptotic process [IMP]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- endothelial cell chemotaxis [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- response to inorganic substance [ISA]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription.
Gene inactivation studies have suggested that the product of the retinoblastoma gene, Rb, is particularly limiting in pituitary pro-opiomelanocortin (POMC)-expressing cell lineages. Indeed, in Rb knock-out mice, these cells develop tumors with high frequency. To understand the implication of limiting Rb expression in these cells, we investigated the action of Rb and its related pocket proteins, p107 and p130, on ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID