BAIT
TCF3
E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
transcription factor 3
GO Process (15)
GO Function (17)
GO Component (7)
Gene Ontology Biological Process
- B cell differentiation [NAS]
- B cell lineage commitment [IDA, NAS]
- immunoglobulin V(D)J recombination [IDA]
- muscle cell differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of B cell proliferation [IMP]
- positive regulation of cell cycle [IDA]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of G1/S transition of mitotic cell cycle [IDA]
- regulation of transcription, DNA-templated [NAS]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, NAS]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- enhancer binding [IC]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, NAS]
- protein homodimerization activity [IDA]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- vitamin D response element binding [IDA]
- DNA binding [IDA, NAS]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- enhancer binding [IC]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, NAS]
- protein homodimerization activity [IDA]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- vitamin D response element binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
SCX
SCXA, SCXB, bHLHa48
scleraxis basic helix-loop-helix transcription factor
GO Process (24)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- Sertoli cell differentiation [ISS]
- cell differentiation [ISS]
- chondrocyte differentiation [ISS]
- collagen fibril organization [ISS]
- deltoid tuberosity development [ISS]
- endochondral ossification [ISS]
- heart valve formation [ISS]
- heart valve morphogenesis [ISS]
- mesoderm formation [ISS]
- negative regulation of apoptotic process [ISS]
- positive regulation of cartilage development [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of collagen biosynthetic process [ISS]
- positive regulation of gastrulation [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of cartilage development [ISS]
- tendon cell differentiation [ISS]
- tendon development [ISS]
- tendon formation [ISS]
- tissue homeostasis [ISS]
- transcription, DNA-templated [IDA, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of interaction partners for the basic-helix-loop-helix protein E47.
Helix-loop-helix proteins constitute a family of transcription factors with the potential to form homo- and hetero-dimers mediated by the helix-loop-helix domain. Oncogenic mutations in such genes can disrupt the equilibrium of protein-protein interactions in the affected cell. In order to assess the biological consequences of such mutations, the full complement of interacting proteins must be known. To identify proteins interacting ... [more]
Oncogene Feb. 27, 1997; 14(8);891-8 [Pubmed: 9050988]
Throughput
- Low Throughput
Curated By
- BioGRID