BAIT

NGLY1

1110002C09Rik, PNGase, Png1
N-glycanase 1
GO Process (1)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

KPNA2

2410044B12Rik, IPOA1, PTAC58, Rch1, RP23-170A23.5
karyopherin (importin) alpha 2
Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation.

Park H, Suzuki T, Lennarz WJ

Peptide:N-glycanase (PNGase) cleaves oligosaccharide chains from glycopeptides and glycoproteins. Recently the deduced amino acid sequence of a cytoplasmic PNGase has been identified in various eukaryotes ranging from yeast to mammals, suggesting that deglycosylation may play a central role in some catabolic process. Several lines of evidence indicate that the cytoplasmic enzyme is involved in the quality control system for newly ... [more]

Proc. Natl. Acad. Sci. U.S.A. Sep. 25, 2001; 98(20);11163-8 [Pubmed: 11562482]

Throughput

  • Low Throughput

Curated By

  • BioGRID