Publication

Examining posttranslational modification-mediated protein-protein interactions using a chemical proteomics approach.

Li X, Foley EA, Kawashima SA, Molloy KR, Li Y, Chait BT, Kapoor TM

Post-translational modifications (PTM) of proteins can control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms it is critical that we can profile the PTM-dependent protein-protein interactions. However, identifying these interactions can be very difficult using available approaches, as PTMs can be dynamic and often mediate relatively weak protein-protein interactions. We have recently ... [more]

Throughput

• Low Throughput

Additional Notes

• binds an HIST3H3-Phos peptide in vitro
• products phto-crosslinked

Curated By

• BioGRID