BAIT

VKORC1

EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR, MSTP134
vitamin K epoxide reductase complex, subunit 1
Homo sapiens
PREY

CNN3

calponin 3, acidic
GO Process (1)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation.

Schaafhausen A, Rost S, Oldenburg J, Mueller CR

Since the discovery of vitamin K epoxide reductase complex subunit 1 (VKORC1), the key enzyme for the regeneration of vitamin KHâ‚‚, numerous studies have addressed the role of VKORC1 in the posttranslational modification of vitamin K-dependent proteins. VKORC1 is also the target protein of anticoagulant drugs of the coumarin type (e.g. warfarin). Genetic variants in VKORC1 have recently been shown ... [more]

Thromb. Haemost. Feb. 01, 2011; 105(2);285-94 [Pubmed: 21103663]

Throughput

  • Low Throughput

Curated By

  • BioGRID