BAIT
VKORC1
EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR, MSTP134
vitamin K epoxide reductase complex, subunit 1
GO Process (7)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP6AP2
APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028
ATPase, H+ transporting, lysosomal accessory protein 2
GO Process (9)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- angiotensin maturation [IDA, TAS]
- cellular protein metabolic process [TAS]
- eye pigmentation [IMP]
- head morphogenesis [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of transforming growth factor beta1 production [IDA]
- proteolysis [EXP]
- regulation of MAPK cascade [IDA]
- rostrocaudal neural tube patterning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation.
Since the discovery of vitamin K epoxide reductase complex subunit 1 (VKORC1), the key enzyme for the regeneration of vitamin KHâ‚‚, numerous studies have addressed the role of VKORC1 in the posttranslational modification of vitamin K-dependent proteins. VKORC1 is also the target protein of anticoagulant drugs of the coumarin type (e.g. warfarin). Genetic variants in VKORC1 have recently been shown ... [more]
Thromb. Haemost. Feb. 01, 2011; 105(2);285-94 [Pubmed: 21103663]
Throughput
- Low Throughput
Curated By
- BioGRID