NDEL1
Gene Ontology Biological Process
- activation of Cdc42 GTPase activity [IDA]
- canonical Wnt signaling pathway [IMP]
- cell migration [IMP]
- central nervous system neuron axonogenesis [IMP]
- centrosome localization [IMP]
- cerebral cortex radially oriented cell migration [IMP]
- chromosome segregation [IBA, ISO]
- establishment of chromosome localization [IBA]
- establishment of mitotic spindle orientation [IBA]
- inner cell mass cell proliferation [IMP]
- microtubule cytoskeleton organization [IGI]
- microtubule nucleation [IBA]
- mitotic centrosome separation [IGI, IMP]
- neurofilament cytoskeleton organization [IMP]
- neuron migration [IGI]
- neuron projection development [ISO]
- neuron projection extension [IGI]
- nuclear envelope disassembly [ISS]
- positive regulation of axon extension [ISO]
- positive regulation of axon regeneration [ISO]
- proteolysis [ISO]
- regulation of neuron projection development [IMP, ISO]
- retrograde axon cargo transport [IDA]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DYNC1H1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons.
The cytoskeleton controls the architecture and survival of central nervous system (CNS) neurons by maintaining the stability of axons and dendrites. Although neurofilaments (NFs) constitute the main cytoskeletal network in these structures, the mechanism that underlies subunit incorporation into filaments remains a mystery. Here we report that NUDEL, a mammalian homologue of the Aspergillus nidulans nuclear distribution molecule NudE, is ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDEL1 DYNC1H1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| NDEL1 DYNC1H1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.934 | BioGRID | 2679868 |
Curated By
- BioGRID