BAIT

NDEL1

2600006O07Rik, MITAP1, NUDEL, mNudel, RP23-396M19.4

nuclear distribution gene E-like homolog 1 (A. nidulans)

GO Process (24)

GO Function (6)

GO Component (13)

Gene Ontology Biological Process

activation of Cdc42 GTPase activity [IDA]

canonical Wnt signaling pathway [IMP]

cell migration [IMP]

central nervous system neuron axonogenesis [IMP]

centrosome localization [IMP]

cerebral cortex radially oriented cell migration [IMP]

chromosome segregation [IBA, ISO]

establishment of chromosome localization [IBA]

establishment of mitotic spindle orientation [IBA]

inner cell mass cell proliferation [IMP]

microtubule cytoskeleton organization [IGI]

microtubule nucleation [IBA]

mitotic centrosome separation [IGI, IMP]

neurofilament cytoskeleton organization [IMP]

neuron migration [IGI]

neuron projection development [ISO]

neuron projection extension [IGI]

nuclear envelope disassembly [ISS]

positive regulation of axon extension [ISO]

positive regulation of axon regeneration [ISO]

proteolysis [ISO]

regulation of neuron projection development [IMP, ISO]

retrograde axon cargo transport [IDA]

vesicle transport along microtubule [IGI]

Gene Ontology Molecular Function

alpha-tubulin binding [IDA]
beta-tubulin binding [IDA]
microtubule binding [IDA]
oligopeptidase activity [ISO]
protein binding [IPI]
protein complex binding [ISO]

Gene Ontology Cellular Component

axon [IDA, ISO]

axon hillock [IDA]

cell body [ISO]

cell leading edge [IDA]

centrosome [IDA, ISO]

cytoplasm [ISO]

kinesin complex [IBA, ISO]

kinetochore [IBA, ISO]

microtubule associated complex [IDA]

microtubule organizing center [IGI]

neurofilament cytoskeleton [IDA]

nuclear envelope [ISS]

nucleolus [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

DCTN1

AL022633, Glued, p150, p150

dynactin 1

GO Process (2)

GO Function (1)

GO Component (10)

Gene Ontology Biological Process

melanosome transport [IMP]

retrograde transport, endosome to Golgi [ISO]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cell leading edge [IDA]

centrosome [ISO]

cytoplasmic dynein complex [ISO]

kinetochore [ISO]

microtubule [ISO]

protein complex [IDA]

retromer complex [ISO]

spindle pole [ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons.

Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng HC, Park SK, Julien JP, Tsai LH

The cytoskeleton controls the architecture and survival of central nervous system (CNS) neurons by maintaining the stability of axons and dendrites. Although neurofilaments (NFs) constitute the main cytoskeletal network in these structures, the mechanism that underlies subunit incorporation into filaments remains a mystery. Here we report that NUDEL, a mammalian homologue of the Aspergillus nidulans nuclear distribution molecule NudE, is ... [more]

Nat. Cell Biol. Jul. 01, 2004; 6(7);595-608 [Pubmed: 15208636]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NDEL1 DCTN1	Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.	Nguyen MD (2004)	Low	-	BioGRID	-

Curated By

BioGRID