NEFL
Gene Ontology Biological Process
- anterograde axon cargo transport [ISO]
- axon transport of mitochondrion [ISO]
- intermediate filament bundle assembly [IGI]
- intermediate filament organization [IMP, ISO]
- locomotion [IMP]
- microtubule cytoskeleton organization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurofilament bundle assembly [ISO]
- neurofilament cytoskeleton organization [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuron projection morphogenesis [IMP]
- peripheral nervous system axon regeneration [IMP]
- positive regulation of axonogenesis [IMP]
- protein polymerization [ISO]
- regulation of axon diameter [IMP]
- retrograde axon cargo transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NEFH
Gene Ontology Biological Process
- axon development [IMP, ISO]
- intermediate filament bundle assembly [IGI, ISO]
- intermediate filament cytoskeleton organization [IMP]
- microtubule cytoskeleton organization [IGI]
- neurofilament bundle assembly [ISO]
- neurofilament cytoskeleton organization [IGI, IMP]
- peripheral nervous system neuron axonogenesis [IMP]
- regulation of organelle transport along microtubule [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons.
The cytoskeleton controls the architecture and survival of central nervous system (CNS) neurons by maintaining the stability of axons and dendrites. Although neurofilaments (NFs) constitute the main cytoskeletal network in these structures, the mechanism that underlies subunit incorporation into filaments remains a mystery. Here we report that NUDEL, a mammalian homologue of the Aspergillus nidulans nuclear distribution molecule NudE, is ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEFL NEFH | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.7675 | BioGRID | 2671753 |
Curated By
- BioGRID