AR
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- activation of prostate induction by androgen receptor signaling pathway [IMP]
- androgen receptor signaling pathway [IDA, ISO]
- cellular process [IDA]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial cell morphogenesis [IGI]
- fertilization [IMP]
- in utero embryonic development [IMP]
- intracellular receptor signaling pathway [ISO]
- lateral sprouting involved in mammary gland duct morphogenesis [IMP]
- male genitalia morphogenesis [IMP]
- male gonad development [IGI, IMP]
- male sex differentiation [ISO]
- male somatic sex determination [IMP]
- mammary gland alveolus development [IMP]
- morphogenesis of an epithelial fold [IMP]
- multicellular organism growth [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of integrin biosynthetic process [ISO]
- organ formation [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [IMP]
- positive regulation of integrin biosynthetic process [ISO]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate gland epithelium morphogenesis [IMP]
- prostate gland growth [IMP]
- protein oligomerization [ISO]
- regulation of catalytic activity [IMP]
- regulation of developmental growth [IMP]
- regulation of establishment of protein localization to plasma membrane [ISO]
- regulation of gene expression [IMP]
- regulation of prostatic bud formation [IGI]
- regulation of systemic arterial blood pressure [IGI]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- reproductive structure development [IMP]
- reproductive system development [IGI]
- seminiferous tubule development [IGI, IMP]
- single fertilization [IGI]
- spermatogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tertiary branching involved in mammary gland duct morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
ACTN2
Gene Ontology Biological Process
- focal adhesion assembly [ISO]
- microspike assembly [ISO]
- muscle contraction [IDA]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein localization to cell surface [ISO]
- positive regulation of potassium ion transmembrane transporter activity [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of receptor activity [IDA]
- protein homotetramerization [ISO]
- regulation of membrane potential [ISO]
- regulation of nucleic acid-templated transcription [IDA]
Gene Ontology Molecular Function- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2.
The p160 coactivators, steroid receptor coactivator 1, glucocorticoid receptor interacting protein 1 (GRIP1) and the activator of thyroid and retinoic acid receptor, have two activation domains, AD1 and AD2, which transmit the activation signal from the DNA-bound nuclear receptor to the chromatin and/or transcription machinery. In screening for mammalian proteins that bind the AD2 of GRIP1, we identified a mouse ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID