TLC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IES5
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Telomerase-null survivor screening identifies novel telomere recombination regulators.
Telomeres are protein-DNA structures found at the ends of linear chromosomes and are crucial for genome integrity. Telomeric DNA length is primarily maintained by the enzyme telomerase. Cells lacking telomerase will undergo senescence when telomeres become critically short. In Saccharomyces cerevisiae, a very small percentage of cells lacking telomerase can remain viable by lengthening telomeres via two distinct homologous recombination ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: telomere length (APO:0000144)
- phenotype: viability (APO:0000111)
Additional Notes
- cells survive the senescence caused by the tlc1 mutation by lengthening their telomeres
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TLC1 IES5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | Low | - | BioGRID | 2200335 |
Curated By
- BioGRID