BAIT

TLC1

TER1, L000002315
RNA template component of telomerase; TLC1 RNA contains a template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; promoter regulated by the cell cycle dependent transcriptional activators Swi4p/Swi6p and Mbp1p/Swi6p
Saccharomyces cerevisiae (S288c)
PREY

IES5

YER092W
Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Telomerase-null survivor screening identifies novel telomere recombination regulators.

Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ

Telomeres are protein-DNA structures found at the ends of linear chromosomes and are crucial for genome integrity. Telomeric DNA length is primarily maintained by the enzyme telomerase. Cells lacking telomerase will undergo senescence when telomeres become critically short. In Saccharomyces cerevisiae, a very small percentage of cells lacking telomerase can remain viable by lengthening telomeres via two distinct homologous recombination ... [more]

PLoS Genet. Jan. 01, 2013; 9(1);e1003208 [Pubmed: 23390378]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: telomere length (APO:0000144)
  • phenotype: viability (APO:0000111)

Additional Notes

  • cells survive the senescence caused by the tlc1 mutation by lengthening their telomeres

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TLC1 IES5
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Low-BioGRID
2200335

Curated By

  • BioGRID