BAIT

TLC1

TER1, L000002315
RNA template component of telomerase; TLC1 RNA contains a template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; promoter regulated by the cell cycle dependent transcriptional activators Swi4p/Swi6p and Mbp1p/Swi6p
Saccharomyces cerevisiae (S288c)
PREY

NMD2

IFS1, SUA1, SUP111, UPF2, L000001257, S000029548, L000002230, YHR077C
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Telomerase-null survivor screening identifies novel telomere recombination regulators.

Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ

Telomeres are protein-DNA structures found at the ends of linear chromosomes and are crucial for genome integrity. Telomeric DNA length is primarily maintained by the enzyme telomerase. Cells lacking telomerase will undergo senescence when telomeres become critically short. In Saccharomyces cerevisiae, a very small percentage of cells lacking telomerase can remain viable by lengthening telomeres via two distinct homologous recombination ... [more]

PLoS Genet. Jan. 01, 2013; 9(1);e1003208 [Pubmed: 23390378]

Throughput

  • Low Throughput

Ontology Terms

  • telomere length (APO:0000144)
  • viability (APO:0000111)

Additional Notes

  • cells survive the senescence caused by the tlc1 mutation by lengthening their telomeres

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TLC1 NMD2
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Low-BioGRID
656957
NMD2 TLC1
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Low-BioGRID
3750989

Curated By

  • BioGRID