TCF4
Gene Ontology Biological Process
- DNA-templated transcription, initiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of neuron differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein-DNA complex assembly [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
MYF5
Gene Ontology Biological Process
- camera-type eye development [IMP]
- cartilage condensation [IMP]
- embryonic skeletal system morphogenesis [IMP]
- extracellular matrix organization [IMP]
- muscle organ development [IGI, IMP]
- muscle organ morphogenesis [IGI]
- muscle tissue morphogenesis [IGI, IMP]
- ossification [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of cell-matrix adhesion [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- skeletal muscle cell differentiation [IMP]
- skeletal muscle tissue development [IGI, IMP]
- somitogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [TAS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation.
The expression of several muscle-specific genes is partially or completely regulated by MCAT elements, which bind members of the TEF family of transcription factors. TEF1 itself is unable to activate reporter plasmids bearing TEF1-binding sites, suggesting that additional bridging or co-activating factors are necessary to allow interaction of TEF1 with the transcriptional machinery. In addition, none of the known TEF ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID