VANGL2
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- Wnt signaling pathway, planar cell polarity pathway [IGI, IMP]
- anterior/posterior pattern specification [IMP]
- apical protein localization [IMP]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell migration involved in kidney development [IMP]
- cochlea development [IGI]
- cochlea morphogenesis [IGI, IMP]
- convergent extension involved in axis elongation [IMP]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- digestive tract morphogenesis [IGI]
- epicardial cell to mesenchymal cell transition [TAS]
- establishment of body hair planar orientation [IMP]
- establishment of epithelial cell polarity [TAS]
- establishment of planar polarity [IGI, IMP]
- establishment of planar polarity involved in neural tube closure [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- glomerulus development [IMP]
- hair follicle development [IMP]
- heart looping [IMP]
- inner ear receptor cell development [IGI]
- inner ear receptor stereocilium organization [IGI, IMP]
- kidney morphogenesis [IMP]
- lateral sprouting involved in lung morphogenesis [IMP]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- neural tube closure [IGI, IMP]
- non-canonical Wnt signaling pathway [IMP]
- nonmotile primary cilium assembly [IGI]
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- outflow tract septum morphogenesis [TAS]
- patterning of blood vessels [TAS]
- planar cell polarity pathway involved in axis elongation [IGI]
- planar cell polarity pathway involved in heart morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- positive regulation of JUN kinase activity [IGI]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of actin cytoskeleton organization [IMP]
- regulation of establishment of planar polarity [IGI]
- somatic stem cell division [IMP]
- somatic stem cell maintenance [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FZD3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- canonical Wnt signaling pathway [IBA, ISO]
- cell proliferation in midbrain [IGI]
- commissural neuron axon guidance [IMP]
- establishment of planar polarity [IGI]
- inner ear morphogenesis [IGI]
- midbrain development [IGI]
- negative regulation of execution phase of apoptosis [IMP]
- negative regulation of mitotic cell cycle, embryonic [IMP]
- neural tube closure [IGI]
- neuron migration [IMP]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of neuroblast proliferation [IMP]
- post-anal tail morphogenesis [IMP]
- sympathetic ganglion development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.
Planar cell polarity (PCP) is a process in which cells develop with uniform orientation within the plane of an epithelium. To begin to elucidate the mechanisms of PCP in vertebrates, the localization of the protein Vangl2 (Van Gogh-like) was determined during the development of the mammalian cochlea. Results indicate that Vangl2 becomes asymmetrically localized to specific cell-cell boundaries along the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID