BAIT
PRKCZ
AI098070, C80388, Pkcz, R74924, aPKCzeta, nPKC-zeta, zetaPKC, RP23-298E4.6
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of phospholipase D activity [ISO]
- activation of protein kinase B activity [ISO]
- cell migration [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [ISO]
- establishment of cell polarity [ISO]
- insulin receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- microtubule cytoskeleton organization [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T-helper 2 cell cytokine production [IMP]
- positive regulation of T-helper 2 cell differentiation [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-13 secretion [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of interleukin-5 secretion [IMP]
- positive regulation of protein transport [ISO]
- positive regulation of synaptic transmission [ISO]
- protein heterooligomerization [ISO]
- protein kinase C signaling [ISO]
- protein localization to plasma membrane [IMP]
- protein phosphorylation [IDA, ISO]
- signal transduction [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [IDA]
- apical plasma membrane [IDA]
- axon hillock [IDA]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell junction [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [ISO]
- microtubule organizing center [IGI]
- myelin sheath abaxonal region [IDA]
- nuclear envelope [IDA]
- nuclear matrix [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [IDA]
Mus musculus
PREY
GSK3B
7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [IDA, ISO]
- Wnt signaling pathway [IGI]
- axonogenesis [IGI]
- canonical Wnt signaling pathway [IDA, ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IMP]
- cell migration [IGI]
- cell proliferation [TAS]
- cellular response to interleukin-3 [IDA]
- cellular response to mechanical stimulus [ISO]
- circadian rhythm [IMP]
- cytoskeleton organization [TAS]
- epithelial to mesenchymal transition [ISO]
- establishment of cell polarity [ISO]
- establishment or maintenance of cell polarity [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- fat cell differentiation [IDA]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [IMP]
- intracellular signal transduction [ISO]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NFAT protein import into nucleus [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy [IDA]
- negative regulation of dendrite morphogenesis [ISO]
- negative regulation of neuron maturation [IGI]
- negative regulation of neuron projection development [IGI, IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [IMP]
- peptidyl-serine phosphorylation [IDA, ISO]
- phosphorylation [IMP]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of axon extension [IGI]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein export from nucleus [IDA]
- protein localization to microtubule [IGI]
- protein phosphorylation [IDA, IGI, IMP, ISO, ISS]
- re-entry into mitotic cell cycle [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of microtubule-based process [IDA, ISO]
- regulation of neuron projection development [IGI]
- regulation of neuronal synaptic plasticity [ISO]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [IDA]
- centrosome [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- dendritic spine [ISO]
- growth cone [IDA]
- membrane [ISO]
- membrane raft [ISO]
- membrane-bounded organelle [IDA]
- neuronal cell body [IDA]
- neuronal postsynaptic density [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [IDA]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Differentiation of skin stem cells into hair follicles (HFs) requires the inhibition of beta-catenin degradation, which is controlled by a complex containing axin and the protein kinase GSK3beta. Using conditional gene targeting in mice, we show now that the small GTPase Cdc42 is crucial for differentiation of skin progenitor cells into HF lineage and that it regulates the turnover of ... [more]
Genes Dev. Mar. 01, 2006; 20(5);571-85 [Pubmed: 16510873]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKCZ GSK3B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID