ZIC2
Gene Ontology Biological Process
- cell differentiation [IMP]
- central nervous system development [IGI]
- developmental pigmentation [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [IMP]
- neural tube closure [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- retinal ganglion cell axon guidance [IMP]
- transcription from RNA polymerase II promoter [IDA]
- visual perception [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
MDFI
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- dorsal/ventral axis specification [IMP]
- embryonic skeletal system morphogenesis [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of Wnt signaling pathway [IDA]
- trophoblast giant cell differentiation [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.
The Zic-family proteins control various developmental processes. Previous studies have shown that Zic1, Zic2, and Zic3 can act as transcriptional regulators, and that their functions are repressed by I-mfa, which has been identified as a repressor for basic helix-loop-helix-type transcriptional factors. Here, we investigated the molecular properties of the Zic4 and Zic5 proteins. Zic4/Zic5 showed DNA-binding activity to the Gli-binding ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID