BAIT
SNAP25
SNAP-25B, SNAP-25a
synaptosomal-associated protein 25
GO Process (17)
GO Function (9)
GO Component (28)
Gene Ontology Biological Process
- axonogenesis [IEP]
- calcium ion-dependent exocytosis of neurotransmitter [IDA]
- endosomal transport [IDA]
- exocytosis [TAS]
- growth hormone secretion [IEP]
- long-term memory [IMP]
- long-term synaptic potentiation [ISO]
- neurotransmitter secretion [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of insulin secretion [IEP]
- potassium ion transmembrane transport [IDA]
- regulation of establishment of protein localization [ISO]
- regulation of neuron projection development [IMP]
- regulation of synapse assembly [IEP]
- sleep [IDA]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BLOC-1 complex [ISO, ISS]
- SNARE complex [IDA, ISO]
- actin cytoskeleton [IDA]
- axon [IDA]
- axonal growth cone [IDA]
- cell [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endosome [IDA]
- filopodium [IDA]
- growth cone [IDA]
- intracellular organelle [IDA]
- lamellipodium [IDA]
- membrane [ISO, ISS]
- membrane raft [IDA]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- synapse [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
- terminal bouton [IDA]
- trans-Golgi network [ISO]
- vesicle [ISO]
- voltage-gated potassium channel complex [IDA]
Rattus norvegicus
PREY
STX1B
Stx1b2, Stx2
syntaxin 1B
GO Process (11)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- intracellular protein transport [IBA]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of neurotransmitter secretion [ISS]
- protein transport [IMP]
- regulation of exocytosis [IMP]
- regulation of gene expression [ISS]
- regulation of synaptic vesicle priming [ISS]
- synaptic vesicle docking [ISS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis.
Synaptosome-associated protein of 25 kDa (SNAP-25) is a neuronal membrane protein essential for synaptic vesicle exocytosis. To investigate the mechanisms by which SNAP-25 mediates neurosecretion, we performed a search for proteins that interact with SNAP-25 using a yeast two-hybrid screen. Here, we report the isolation and characterization of a SNAP-25-interacting protein that is the rat homologue of mouse hepatocyte growth ... [more]
J. Cell. Sci. Jun. 01, 2000; 113(0);2273-84 [Pubmed: 10825299]
Throughput
- Low Throughput
Curated By
- BioGRID