RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- Ras protein signal transduction [ISO]
- cell cycle arrest [ISO]
- cell division [ISO]
- cell morphogenesis involved in neuron differentiation [ISO]
- digestive tract development [ISO]
- enucleate erythrocyte differentiation [ISO]
- glial cell apoptotic process [ISO]
- hepatocyte apoptotic process [IMP, ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- myoblast differentiation [ISO, ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell cycle [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of smoothened signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [ISO]
- neuron differentiation [ISO]
- neuron maturation [ISO]
- neuron projection development [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein localization to chromosome, centromeric region [ISO]
- regulation of cell cycle [ISO]
- regulation of cohesin localization to chromatin [ISO]
- regulation of lipid kinase activity [ISO, ISS]
- regulation of mitotic cell cycle [ISO]
- sister chromatid biorientation [ISO]
- skeletal muscle cell differentiation [ISO]
- striated muscle cell differentiation [ISO]
Gene Ontology Molecular Function
DGKZ
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- lamellipodium [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.
The retinoblastoma protein (pRB) is a tumor suppressor and key regulator of the cell cycle. We have previously shown that pRB interacts with phosphatidylinositol-4-phosphate 5-kinases, lipid kinases that can regulate phosphatidylinositol 4,5-bisphosphate levels in the nucleus. Here, we investigated pRB binding to another lipid kinase in the phosphoinositide cycle, diacylglycerol kinase (DGK) that phosphorylates the second messenger diacylglycerol to yield ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID