Publication

The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.

Los AP, Vinke FP, de Widt J, Topham MK, van Blitterswijk WJ, Divecha N

The retinoblastoma protein (pRB) is a tumor suppressor and key regulator of the cell cycle. We have previously shown that pRB interacts with phosphatidylinositol-4-phosphate 5-kinases, lipid kinases that can regulate phosphatidylinositol 4,5-bisphosphate levels in the nucleus. Here, we investigated pRB binding to another lipid kinase in the phosphoinositide cycle, diacylglycerol kinase (DGK) that phosphorylates the second messenger diacylglycerol to yield ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID