An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.

Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA

G-protein-coupled receptors (GPCRs) are regulated by a complex network of mechanisms such as oligomerization and internalization. Using the GPCR subtypes for thyrotropin-releasing hormone (TRHR1 and TRHR2), the aim of this study was to determine if subtype-specific differences exist in the trafficking process. If so, we wished to determine the impact of homo- and hetero-oligomerization on TRHR subtype trafficking as a ... [more]

J. Biol. Chem. Dec. 27, 2002; 277(52);50422-30 [Pubmed: 12393857]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TRHR TRHR	FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.	Kroeger KM (2001)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

TRHR

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein homodimerization activity [IDA]thyrotropin-releasing hormone receptor activity [IDA]

Gene Ontology Cellular Component