BAIT
CAV3
AI385751, Cav-3, M-cav
caveolin 3
GO Process (54)
GO Function (12)
GO Component (17)
Gene Ontology Biological Process
- actin filament organization [IMP]
- cardiac muscle cell development [IMP]
- caveola assembly [IMP, ISO]
- cholesterol homeostasis [IMP]
- cytoplasmic microtubule organization [IMP]
- endocytosis [IMP, TAS]
- establishment of protein localization to plasma membrane [IMP]
- glucose homeostasis [IMP]
- heart trabecula formation [IMP]
- membrane raft organization [IMP]
- muscle cell cellular homeostasis [IMP]
- myoblast fusion [IMP]
- myotube differentiation [IMP]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of MAPK cascade [IMP]
- negative regulation of calcium ion transport [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy [IMP, ISO]
- negative regulation of cell growth involved in cardiac muscle cell development [ISO]
- negative regulation of cell size [ISO]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein kinase activity [IMP]
- negative regulation of sarcomere organization [ISO]
- nucleus localization [IMP]
- plasma membrane organization [IMP]
- plasma membrane repair [IMP]
- positive regulation of caveolin-mediated endocytosis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of myotube differentiation [IMP]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [IMP]
- regulation of branching involved in mammary gland duct morphogenesis [IMP]
- regulation of calcium ion import [ISO]
- regulation of calcium ion transmembrane transporter activity [ISO]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle contraction [ISO]
- regulation of heart contraction [ISO]
- regulation of heart rate [ISO]
- regulation of membrane depolarization during cardiac muscle cell action potential [ISO]
- regulation of membrane potential [IGI, ISO]
- regulation of nerve growth factor receptor activity [ISO]
- regulation of p38MAPK cascade [IMP]
- regulation of protein kinase B signaling [IMP]
- regulation of signal transduction by receptor internalization [ISO]
- regulation of skeletal muscle contraction [ISO]
- regulation of sodium ion transmembrane transporter activity [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- triglyceride metabolic process [IMP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- alpha-tubulin binding [IDA]
- calcium channel regulator activity [ISO]
- connexin binding [IPI, ISO]
- enzyme binding [ISO]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- sodium channel regulator activity [ISO]
- alpha-tubulin binding [IDA]
- calcium channel regulator activity [ISO]
- connexin binding [IPI, ISO]
- enzyme binding [ISO]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- T-tubule [IDA, ISO]
- Z disc [ISO]
- caveola [IDA, ISO]
- cell [IMP]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dystrophin-associated glycoprotein complex [ISO]
- endoplasmic reticulum [ISO]
- intercalated disc [ISO]
- membrane [IDA]
- membrane raft [IDA]
- neuromuscular junction [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- vesicle [ISO]
Mus musculus
PREY
DMD
DXSmh7, DXSmh9, Dp427, Dp71, dys, mdx, pke, RP23-58B9.1
dystrophin, muscular dystrophy
GO Process (34)
GO Function (7)
GO Component (16)
Gene Ontology Biological Process
- cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [ISO]
- cellular protein complex assembly [IMP]
- cellular protein localization [IMP, ISO]
- establishment of blood-nerve barrier [IMP]
- establishment of glial blood-brain barrier [IMP]
- muscle cell cellular homeostasis [IMP]
- muscle fiber development [IGI]
- muscle organ development [IMP]
- myotube cell development [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of peptidyl-cysteine S-nitrosylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- neurotransmitter receptor metabolic process [IMP]
- nucleus localization [IMP]
- olfactory nerve structural organization [IMP]
- peptide biosynthetic process [ISO]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IMP]
- regulation of cellular response to growth factor stimulus [ISO]
- regulation of gene expression [IMP]
- regulation of heart rate [IMP, ISO]
- regulation of membrane potential [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- regulation of ryanodine-sensitive calcium-release channel activity [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of voltage-gated calcium channel activity [IMP]
- response to muscle stretch [IMP]
- skeletal muscle tissue development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell [IMP]
- cell surface [ISO]
- cell-substrate junction [IDA]
- costamere [ISO]
- dystrophin-associated glycoprotein complex [IDA, ISO]
- filopodium [ISO]
- filopodium membrane [ISO]
- intracellular [IMP]
- membrane raft [IDA]
- neuron projection terminus [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins.
Caveolae are microdomains of the plasma membrane that have been implicated in signal transduction. Caveolin, a 21-24-kDa integral membrane protein, is a principal component of the caveolae membrane. Recently, we and others have identified a family of caveolin-related proteins; caveolin has been retermed caveolin-1. Caveolin-3 is most closely related to caveolin-1, but caveolin-3 mRNA is expressed only in muscle tissue ... [more]
J. Biol. Chem. Jun. 21, 1996; 271(25);15160-5 [Pubmed: 8663016]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DMD CAV3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID