KL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FGFR1
Gene Ontology Biological Process
- angiogenesis [IGI]
- auditory receptor cell development [IMP]
- blood vessel morphogenesis [IMP]
- brain development [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- cell maturation [IMP]
- chondrocyte differentiation [IGI]
- embryonic limb morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, ISO]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- generation of neurons [IMP]
- in utero embryonic development [IGI]
- inner ear morphogenesis [IMP]
- lung development [IGI, IMP]
- lung-associated mesenchyme development [IGI]
- mesenchymal cell differentiation [IGI]
- midbrain development [IGI, IMP]
- middle ear morphogenesis [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- orbitofrontal cortex development [IMP]
- organ induction [IMP]
- outer ear morphogenesis [IMP]
- paraxial mesoderm development [IGI]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [IGI]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP, ISO]
- positive regulation of mesenchymal cell proliferation [IGI, IMP]
- positive regulation of neuron projection development [IGI]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [IDA]
- regulation of cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- regulation of gene expression [IMP]
- regulation of lateral mesodermal cell fate specification [IGI]
- salivary gland morphogenesis [IMP]
- sensory perception of sound [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of fibroblast growth factor-23 signaling by klotho.
The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the possibility that Klotho and FGF23 may function in a common signal transduction pathway(s), we investigated whether Klotho is involved in FGF signaling. Here we show ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KL FGFR1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.94 | BioGRID | 2680441 |
Curated By
- BioGRID