MAP2K4
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [IPI]
- activation of JUN kinase activity [IBA, ISO]
- cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAPK10
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.
P19 embryonic carcinoma cells, a model system for studying early development and differentiation, can differentiate into neurons and primitive endoderm-like cells depending on the culture conditions. We have previously reported that the activation of c-Jun amino-terminal kinase (JNK) is required for the retinoic acid-induced neural differentiation of P19 cells. However, the signaling pathway(s) responsible for the activation of JNK has ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MAP2K4 MAPK10 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.943 | BioGRID | 2670628 |
Curated By
- BioGRID