An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.

Akiyama S, Yonezawa T, Kudo TA, Li MG, Wang H, Ito M, Yoshioka K, Ninomiya-Tsuji J, Matsumoto K, Kanamaru R, Tamura S, Kobayashi T

P19 embryonic carcinoma cells, a model system for studying early development and differentiation, can differentiate into neurons and primitive endoderm-like cells depending on the culture conditions. We have previously reported that the activation of c-Jun amino-terminal kinase (JNK) is required for the retinoic acid-induced neural differentiation of P19 cells. However, the signaling pathway(s) responsible for the activation of JNK has ... [more]

J. Biol. Chem. Aug. 27, 2004; 279(35);36616-20 [Pubmed: 15218018]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

MAP2K7

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [ISO]JUN kinase kinase activity [IBA, ISO]MAP kinase kinase activity [IDA, ISO]magnesium ion binding [IDA, ISO]mitogen-activated protein kinase kinase kinase binding [ISO]protein C-terminus binding [ISO]protein binding [IPI]protein kinase binding [ISO]protein phosphatase binding [IPI]

Gene Ontology Cellular Component

MAPK10