BAIT
SNX9
2700073N08Rik, SDP1, SH3PX1
sorting nexin 9
GO Process (13)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- cleavage furrow formation [ISO]
- endocytosis [IBA, ISO]
- endosomal transport [ISO]
- intracellular protein transport [IMP, ISO]
- lipid tube assembly [ISO]
- membrane tubulation [ISO]
- mitotic cytokinesis [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein oligomerization [ISO]
- receptor-mediated endocytosis [ISO]
- vesicle organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IMP]
- clathrin-coated vesicle [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IBA, ISO]
- cytoplasmic vesicle membrane [ISO]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- extrinsic component of membrane [IBA]
- intracellular [IMP]
- plasma membrane [IDA, ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
INSR
4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
insulin receptor
GO Process (43)
GO Function (20)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- activation of protein kinase activity [ISO]
- cellular response to growth factor stimulus [IDA]
- cellular response to insulin stimulus [ISO]
- epidermis development [IMP]
- exocrine pancreas development [IMP]
- glucose homeostasis [ISO]
- heart morphogenesis [ISO]
- insulin receptor signaling pathway [IMP, ISO]
- intracellular signal transduction [ISO]
- male sex determination [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transporter activity [ISO]
- organ morphogenesis [IMP]
- peptidyl-tyrosine autophosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of developmental growth [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glycogen biosynthetic process [IMP, ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of glycoprotein biosynthetic process [ISO]
- positive regulation of mitosis [IMP, ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of respiratory burst [ISO]
- protein autophosphorylation [ISO]
- protein heterotetramerization [ISO]
- protein phosphorylation [ISO]
- regulation of embryonic development [ISO]
- regulation of hydrogen peroxide metabolic process [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction by phosphorylation [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- PTB domain binding [ISO]
- insulin binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-activated receptor activity [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor II binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- lipoic acid binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor signaling protein tyrosine kinase activity [ISO]
- 3-phosphoinositide-dependent protein kinase binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- PTB domain binding [ISO]
- insulin binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-activated receptor activity [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor II binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- lipoic acid binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor signaling protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action.
SNX9 (sorting nexin 9) is one member of a family of proteins implicated in protein trafficking. This family is characterized by a unique PX (Phox homology) domain that includes a proline-rich sequence and an upstream phospholipid binding domain. Many sorting nexins, including SNX9, also have a C-terminal coiled region. SNX9 additionally has an N-terminal SH3 (Src homology 3) domain. Here ... [more]
Biochem. J. Nov. 15, 2003; 376(0);123-34 [Pubmed: 12917015]
Throughput
- Low Throughput
Curated By
- BioGRID