SNX9
Gene Ontology Biological Process
- cleavage furrow formation [ISO]
- endocytosis [IBA, ISO]
- endosomal transport [ISO]
- intracellular protein transport [IMP, ISO]
- lipid tube assembly [ISO]
- membrane tubulation [ISO]
- mitotic cytokinesis [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein oligomerization [ISO]
- receptor-mediated endocytosis [ISO]
- vesicle organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IMP]
- clathrin-coated vesicle [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IBA, ISO]
- cytoplasmic vesicle membrane [ISO]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- extrinsic component of membrane [IBA]
- intracellular [IMP]
- plasma membrane [IDA, ISO]
- trans-Golgi network [ISO]
IGF1R
Gene Ontology Biological Process
- axonogenesis [ISO]
- brain development [IMP]
- epidermis development [IMP]
- establishment of cell polarity [ISO]
- exocrine pancreas development [IMP]
- immune response [ISO]
- inactivation of MAPKK activity [ISO]
- insulin-like growth factor receptor signaling pathway [IC, ISO]
- male sex determination [IMP]
- mammary gland development [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- neuron projection development [ISO]
- organ morphogenesis [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, ISO]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of mitosis [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of steroid hormone biosynthetic process [ISO]
- prostate gland epithelium morphogenesis [IMP]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IDA]
- protein tetramerization [ISO]
- regulation of JNK cascade [ISO]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action.
SNX9 (sorting nexin 9) is one member of a family of proteins implicated in protein trafficking. This family is characterized by a unique PX (Phox homology) domain that includes a proline-rich sequence and an upstream phospholipid binding domain. Many sorting nexins, including SNX9, also have a C-terminal coiled region. SNX9 additionally has an N-terminal SH3 (Src homology 3) domain. Here ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IGF1R SNX9 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.755 | BioGRID | 2686616 |
Curated By
- BioGRID