GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [ISO]
- anatomical structure formation involved in morphogenesis [IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- cell differentiation [IMP]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [IDA]
- protein heterooligomerization [ISO]
- receptor internalization [ISO]
- regulation of MAPK cascade [IGI]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
NF2
Gene Ontology Biological Process
- Schwann cell proliferation [ISO]
- actin cytoskeleton organization [ISO]
- brain development [IMP]
- cell-cell junction organization [IMP]
- ectoderm development [IMP]
- hippocampus development [IMP]
- lens fiber cell differentiation [IMP]
- mesoderm formation [IMP]
- negative regulation of DNA replication [ISO]
- negative regulation of JAK-STAT cascade [ISO]
- negative regulation of MAPK cascade [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of protein kinase activity [IDA, IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of stress fiber assembly [ISO]
- regulation of cell proliferation [IMP]
- regulation of hippo signaling [ISO]
- regulation of neural precursor cell proliferation [IMP]
- regulation of protein localization to nucleus [IMP]
- regulation of protein stability [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- adherens junction [IMP]
- apical part of cell [IDA]
- cleavage furrow [IDA]
- cortical actin cytoskeleton [IDA]
- cytoplasm [IDA, ISO]
- cytoskeleton [IDA]
- early endosome [ISO]
- filopodium [IDA]
- lamellipodium [IDA]
- membrane [ISO]
- membrane raft [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ruffle [IDA]
- synapse [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein.
Numerous studies have suggested that the NF2 protein merlin is involved in the regulation of abnormal cell growth and proliferation. In this study, to better understand the merlin's mechanisms that contribute to the inhibition of tumorigenesis, we examined the potential action of merlin on the cell proliferative signaling pathways in response to growth hormone (GH). Merlin effectively attenuated the GH-induced ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NF2 GRB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID