PRNP
Gene Ontology Biological Process
- cellular response to drug [ISO]
- learning or memory [IMP]
- negative regulation of T cell receptor signaling pathway [ISO]
- negative regulation of activated T cell proliferation [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of calcineurin-NFAT signaling cascade [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-17 production [ISO]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of potassium ion transmembrane transport [ISO]
- regulation of protein localization [ISO]
- response to cadmium ion [IDA]
- response to copper ion [IDA]
- response to oxidative stress [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAGED1
Gene Ontology Biological Process
- JUN phosphorylation [TAS]
- circadian regulation of gene expression [ISO, ISS]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of circadian rhythm [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of PrP with NRAGE, a protein involved in neuronal apoptosis.
Prion diseases involve the conversion of the endogenous prion protein, PrP(C), into a disease-associated form PrP(Sc). Reports show that a subset of PrP(C) is subject to degradation in the cytosol by the ubiquitin-proteasome system. Some studies show that cytosolic PrP(C) is neuroprotective, while others show that it is neurotoxic. Here, we report that cytosolic PrP(C) constructs interact with a pro-apoptotic ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAGED1 PRNP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID