BAIT
SOCS2
8030460M17, AI527257, AW108012, CIS2, Cish2, D130043N08Rik, JAB, SOCS-2, SSI-2, hg
suppressor of cytokine signaling 2
GO Process (13)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [IBA]
- growth hormone receptor signaling pathway [ISO]
- intracellular signal transduction [IMP]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- negative regulation of JAK-STAT cascade [IGI]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of multicellular organism growth [IGI, IMP]
- negative regulation of protein kinase activity [IBA]
- positive regulation of neuron differentiation [IDA]
- regulation of multicellular organism growth [IMP]
- response to estradiol [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CUL5
4921514I20Rik, 8430423K24Rik, AI852817, C030032G03Rik, C330021I08Rik, VACM-1, VACM1
cullin 5
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A complex interaction pattern of CIS and SOCS2 with the leptin receptor.
Hypothalamic leptin receptor signalling plays a central role in weight regulation by controlling fat storage and energy expenditure. In addition, leptin also has direct effects on peripheral cell types involved in regulation of diverse body functions including immune response, bone formation and reproduction. Previous studies have demonstrated the important role of SOCS3 (suppressor of cytokine signalling 3) in leptin physiology. ... [more]
J. Cell. Sci. Jun. 01, 2006; 119(0);2214-24 [Pubmed: 16684815]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CUL5 SOCS2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID