SCC2
Gene Ontology Biological Process
- 2-micrometer plasmid partitioning [IC]
- double-strand break repair [IMP]
- establishment of mitotic sister chromatid cohesion [IMP]
- establishment of protein localization to chromatin [IMP]
- mitotic chromosome condensation [IMP]
- protein localization to chromatin [IMP]
- rDNA condensation [IMP]
- replication-born double-strand break repair via sister chromatid exchange [IMP]
- tRNA gene clustering [IMP]
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
Gene Ontology Cellular Component
EAF3
Gene Ontology Biological Process
- DNA repair [IDA]
- histone acetylation [IDA]
- histone deacetylation [IMP]
- negative regulation of antisense RNA transcription [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- regulation of DNA-dependent DNA replication initiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- transcription elongation from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators.
Synthetic lethality has been proposed as a way to leverage the genetic differences found in tumor cells to affect their selective killing. Cohesins, which tether sister chromatids together until anaphase onset, are mutated in a variety of tumor types. The elucidation of synthetic lethal interactions with cohesin mutants therefore identifies potential therapeutic targets. We used a cross-species approach to identify ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- p-value less than 0.05 and a large interaction magnitude (E-C value less than -0.3)
- scc2-4 allele
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SCC2 EAF3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID