BAIT
NR3C1
GR, Gcr, Grl
nuclear receptor subfamily 3, group C, member 1
GO Process (41)
GO Function (25)
GO Component (10)
Gene Ontology Biological Process
- adrenal gland development [ISO]
- aging [IEP]
- androgen metabolic process [IEP]
- brain development [IEP]
- cellular response to dexamethasone stimulus [IMP]
- cellular response to magnesium ion [IEP]
- cellular response to steroid hormone stimulus [ISO, ISS]
- chromatin remodeling [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- circadian rhythm [IEP]
- glucocorticoid mediated signaling pathway [ISO]
- glucocorticoid metabolic process [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- lung development [IEP]
- mammary gland duct morphogenesis [ISO]
- maternal behavior [ISO]
- muscle atrophy [IEP]
- negative regulation of glucocorticoid mediated signaling pathway [ISO]
- negative regulation of synaptic plasticity [IMP]
- negative regulation of vascular permeability [IMP]
- positive regulation of cell growth involved in cardiac muscle cell development [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [IDA]
- positive regulation of glutamate secretion [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- regulation of cell proliferation [IDA]
- regulation of glucocorticoid biosynthetic process [ISO]
- regulation of gluconeogenesis [ISO]
- regulation of glucose metabolic process [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to activity [IEP]
- response to arsenic-containing substance [IDA]
- response to calcium ion [IEP]
- response to corticosterone [IEP]
- response to dexamethasone [IEP]
- response to electrical stimulus [IEP]
- response to inactivity [IEP]
- response to insulin [IEP]
- response to mercury ion [IEP]
- response to radiation [IEP]
Gene Ontology Molecular Function- DNA binding [ISO]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [IDA]
- glucocorticoid receptor activity [ISO]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [ISO, ISS]
- heat shock protein binding [IDA]
- hormone binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein dimerization activity [ISO, TAS]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- receptor tyrosine kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, ISS]
- steroid binding [IPI, ISO]
- steroid hormone binding [ISO, ISS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [TAS]
- DNA binding [ISO]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [IDA]
- glucocorticoid receptor activity [ISO]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [ISO, ISS]
- heat shock protein binding [IDA]
- hormone binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein dimerization activity [ISO, TAS]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- receptor tyrosine kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, ISS]
- steroid binding [IPI, ISO]
- steroid hormone binding [ISO, ISS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSP90AA1
Hsp86, Hsp90, Hspca
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (16)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IEP]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [IMP]
- positive regulation of cardiac muscle contraction [IEP]
- positive regulation of cell size [IMP]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of protein import into nucleus, translocation [IMP]
- protein folding [TAS]
- protein import into mitochondrial outer membrane [ISO]
- regulation of catalytic activity [ISO, ISS]
- response to estrogen [IEP]
- response to heat [IEP]
- response to salt stress [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border membrane [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular matrix [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain.
Glucocorticoid receptors (GRs) must heterocomplex with hsp90 to have an open steroid binding cleft that can be accessed by steroid. We reported that a seven-amino acid sequence (547-553 of rat GR) overlapping the amino-terminal end of the ligand binding domain is required for hsp90 binding to GR. We have now conducted saturation mutagenesis of this sequence, which appears to be ... [more]
J. Biol. Chem. Sep. 27, 2002; 277(39);36223-32 [Pubmed: 12145311]
Throughput
- Low Throughput
Curated By
- BioGRID