GTF3C1
Gene Ontology Cellular Component
IGHMBP2
Gene Ontology Biological Process
Gene Ontology Molecular Function- ATP binding [ISO]
- ATP-dependent 5'-3' DNA helicase activity [ISO]
- ATP-dependent 5'-3' RNA helicase activity [ISO]
- DNA binding [ISO]
- DNA-dependent ATPase activity [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA-dependent ATPase activity [ISO]
- ribosome binding [IDA, ISO]
- tRNA binding [ISO]
- transcription factor binding [ISO]
- ATP binding [ISO]
- ATP-dependent 5'-3' DNA helicase activity [ISO]
- ATP-dependent 5'-3' RNA helicase activity [ISO]
- DNA binding [ISO]
- DNA-dependent ATPase activity [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA-dependent ATPase activity [ISO]
- ribosome binding [IDA, ISO]
- tRNA binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.
The human motor neuron degenerative disease spinal muscular atrophy with respiratory distress type 1 (SMARD1) is caused by loss of function mutations of immunoglobulin mu-binding protein 2 (IGHMBP2), a protein of unknown function that contains DNA/RNA helicase and nucleic acid-binding domains. Reduced IGHMBP2 protein levels in neuromuscular degeneration (nmd) mice, the mouse model of SMARD1, lead to motor neuron degeneration. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IGHMBP2 GTF3C1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID